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Tetrahydrobiopterin is a cofactor necessary for the synthesis of tyrosine hydroxylase, a rate-limiting enzyme in dopamine production [134, 135]
On the contrary, the catalytic activity measured with PNP-butyrate is quite low for both enzymes (100 M 1 s 1 ) due to a lower affinity for the substrate and a lower turnover number
123 ToluP.MasiF.LeggioB.ScheggiS.TagliamonteA.De MontisM
He serves as the Chief of Family Medicine and Residency Director at North Caddo Medical Center where he has built his thriving practice over the last 15 years
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