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Despite no experimental manipulation of the contralateral, intact nerves, terminal labeling expanded both rostrocaudally and mediolaterally

The authors concluded that larazotide acetate reduced IEB permeability assessed by lactulose/mannitol permeability test, proinflammatory cytokine production, and gastrointestinal symptoms in CD after gluten exposure (279)
23,6870,84,86 Defects of barrier-forming tight junctions, for example, ZO-1, occludin, claudin-1, claudin-4, and tricellulin, have been implicated in the leak pathway

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Conclusion In summary, ibuprofen is indeed associated with an increased risk of constipation
