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Cortisone injections are typically placed directly into or around a painful joint, bursa, or tendon region to reduce local inflammation

MJH and HTL contribute to this work equally

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136 In contrast, regular physical activity is an important determinant in maintaining an optimal state of health, reducing oxidative stress and preventing chronic diseases, but these beneficial effects are related to the features of physical exercise, especially intensity

There is a poor understanding of their specific functions, as structural information for most of them is unavailable 21

Indeed, other studies have proposed such shuttle systems to supply demyelinated axons with lactate as an important energy sourcenamely, the astrocyte-axon lactate shuttle (Cambron et al., 2015) and the oligodendrocyte-axon lactate shuttle (Campbell et al., A common thread seen in these studies of neurodegenerative diseases is the perturbation of lactate