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ClinicalTrials.gov Rosenstock J, Frias JP, Jastreboff AM, et al
Statistical approaches are usually employed to explore the parameter space and identify which parameters have the greatest influence on model behaviour (Aldridge et al., Reference Aldridge, Burke, Lauffenburger and Sorger2006
Weber and Declerck 1997
8 , e1002466 (2012)
Lack of spontaneous vascularization, which has two main effects: hypoxia and limited nutrient diffusion
