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PD-linked mutations may interfere with any of these pathways, leading, e.g., to decreased lysosomal degradation of -synuclein aggregates or increased aggregation of -synuclein due to oxidative damage downstream of ROS release from defective mitochondria

C.BauseweinD.AllerI.HellR.DickT

Cellular magnesium homeostasis

The advantages of this molecule include its small size which ensures good NMJ penetration, ability to concomitantly administer IVIg therapy since this is not an antibody and the potential for self-administration (given the once daily subcutaneous route of delivery) [85]

Acute Med

Open field test (OFT) The OFT can provide quantitative measurements of animal locomotory and exploratory behavior