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Biol Psychiatr
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Acta 1641 (1), 3541

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doi: 10.1186/s12885-016-2882-0

It was well established that the hepatotoxicity of APAP begins with the metabolic conversion of APAP to its reactive metabolite (N/-acetyl-p-benzoquinone imine, or NAPQI) (Wallace, 2004)