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Once in the cytosol, AIF and endonuclease G (both of which contain nuclear localization sequences [108]) translocate to the nucleus [107], where endonuclease G cleaves DNA every 50-300kb [109], thereby generating DNA fragments typically seen after APAP overdose [41,110] (Figure 1)

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10.1016/j.ijpharm.2019.118448 10 AsarchA.BarakO.LooD

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