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Stage 2: Cellular Depletion As the deficiency progresses, cellular depletion of B12 sets in, leading to cellular dysfunction
This results in -helix 15 being displaced by 8 and -helix 16 by as much as 11 from their original position (Fig
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Moreover, it activates the Nrf2 pathway, inducing the expression of antioxidant and detoxification enzymes to reinforce cellular antioxidant capacity
doi: 10.3390/antiox11010055 57 LiuLWangBYangWJiangQLoorJJOuyangLet al
