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NA-Ir targets mitochondrial DNA ( mtDNA ) and activates the cGAS-STING pathway to induce ferritinophagy ( Autophagy ), while also generating reactive oxygen species ( ROS ) through photodynamic therapy (PDT), depleting glutathione ( GSH ), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis

Sajith, M., Pawar, A., Bafna, V

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OAS1 induces endothelial dysfunction and promotes monocyte adhesion through the NFB pathway in atherosclerosis

it is also conjugated to drugs to make them more water soluble and is involved in amino acid transport across cell membranes Polyamine: any of a family of organic compounds having 2 or more primary amino groups (NH 2 ), biologically important polyamines are involved in DNA replication, ion channel modulation, and blood-brain barrier permeability Several amino acids possess distinct biochemical functions unrelated to their roles in protein synthesis and as sources of oxidizable carbon