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doi: 10.1055/s-0041-1730921 25 FlemmingH

Secondly, it may activate short-chain fatty acid receptors (SCFA receptors) and inhibit histone deacetylase (HDAC) activity, thereby lifting transcriptional repression on key iron absorption genes (such as Dcytb and Ferroportin) and consequently upregulating intestinal iron uptake

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Of those letters, 94 were based on an on-site inspection of the company, 27 were the result of records requests sent under section 704(a)(4) of the Federal Food, Drug, and Cosmetic Act (FD&C Act), six stemmed from testing product samples, and the remainder were generally based on review of product labels, registration materials, and/or websites

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