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Metabolic reprogramming for cancer cells and their microenvironment: beyond the Warburg effect

Moringa oleifera seed oil modulates redox imbalance and iNOS/NFB/caspase3 signaling pathway to exert antioxidant, antiinflammatory and antiapoptotic mechanisms against anticancer drug 5fluorouracilinduced nephrotoxicity in rats

In liver cancer, caraglipzin (CANA) can reduce aerobic glycolysis in HCC by targeting pyruvate kinase M2 (PKM2)

Studies on the evaluation of the association between GPx1 and atherosclerosis variants in Japanese patients with type 2 diabetes, with four polymorphisms, reported that functional variants of the GPx1 gene are associated with increased mean intima-media (IMT) thickness of carotid arteries and cardiovascular risk and peripheral vascular disease in type 2 diabetics [63]

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If these are high, it often means there is a "traffic jam" in the bile ducts or the liver is being signaled by other parts of the body (like the adrenal glands) to produce more