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The plates were incubated for 3 hours at 37 C incubator with 5% CO2, after centrifugation 700 g for 5 minutes

Conversely, the mitochondrial damage and calcium homeostasis imbalance triggered by NLRP3 activation further exacerbate mtROS production, creating a positive feedback amplification loop

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Clearance takes longer in elderly patients, those with liver impairment, and CYP2C19 poor metabolizers

One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [4447] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]