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In obesity, NNMT activity is unusually high in fat cells, which means a lot of nicotinamide gets thrown out before it can be turned into NAD+

10.1038/s41586-021-03510-6 Nature 121 KlemmensenM

Finally, the quantification of mtDNA copy number provided molecular evidence of changes in mitochondrial content

You should consult with a healthcare provider to determine the appropriate dosage for your specific situation

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