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Overdosage and underdosage relative to the prescribed dosageboth aspects of failure of adherencecan frequently be detected by concentration measurements when gross deviations from expected values are obtained

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Curr Atheroscler Rep 11:434439 [DOI] [PubMed] [Google Scholar] Rice-Evans C, Miller NJ (1994) Total antioxidant status in plasma and body fluids

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Moreover, although hormone replacement therapy is effective in improving bone density, long-term use may increase the risk of breast cancer and cardiovascular disease [69]
