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[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Foust K.D., Wang X., McGovern V.L., Braun L., Bevan A.K., Haidet A.M., Le T.T., Morales P.R., Rich M.M., Burghes A.H.M., et al

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This activation is accompanied by a loss of cellular retinoids, and the synthesis of -smooth muscle actin (-SMA), and large quantities of the major components of the extracellular matrix including collagen types I, III, and IV, fibronectin, laminin and proteoglycans

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Severity Classification Mild Side Effects (Most Common): Characterized by symptoms that are noticeable but do not significantly interfere with daily activities

Rheumatoid arthritis is the best example of an inflammatory disease