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Notably, free copper is abundant in the human body, while other copper-binding proteins are scarce

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For adults over 19, the recommended daily intake (RDI) is 2.4 micrograms (mcg)

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Furthermore, NADPH is replenished by the isocitrate dehydrogenase (IDH1/IDH2) branch of the citric acid cycle (TCA cycle), malic enzyme (ME1), and one-carbon metabolism (such as the folate cycle) depending on cell type or nutritional status