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Additionally, fatty acid oxidation is inhibited by suppression of carnitine palmitoyltransferase-1 (CPT1)-a rate-limiting enzyme in the transport of long-chain fatty acyl-CoA into mitochondriavia activation of acetyl-CoA carboxylase (ACC) [40]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 167.Gillam J.E., MacPhee C.E

In addition, the mitochondrial Ca 2+ uniporter (MCU) and mitochondrial permeability transition pore (mPTP) have been proposed as pathways for iron entry into mitochondria [87, 88], and blocking MCU by Ru360 reduced mitochondrial iron uptake and showed higher efficacy than blocking the mPTP with cyclosporin A as it leads to more profound decreases mitochondrial ROS levels and increased mitochondrial function, indicating that MCU may be a crucial portal for iron uptake by mitochondria [89]