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Inflammation of the intestinal tract or abnormal immune response can cause Crohns Disease and Ulcerative Colitis that lead to problems such as cramping, loss of appetite, abdominal pain, persistent diarrhea, fatigue, and blood in the stool

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We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)