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The importance of peroxynitrite in mediating APAP-induced liver injury is also illustrated by the fact that direct scavenging of peroxynitrite by mitochondrial GSH49,50 or resveratrol51 also prevented protein nitration and protected against APAP-induced liver injury

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When glutathione levels drop, your body also becomes less efficient at using the Vitamin C and Vitamin E you get from your diet

Similarly, high-dose intraperitoneal NAC injections caused microglial mortality in the brains of mice

Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-Jun n-terminal kinase

Theranostics 15 (9), 37813796