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2.3.3 Sphingosine-1-phosphate receptor 2: potential crosstalk with conjugated bile acids in TIME Beyond receptors primarily sensing unconjugated or secondary BAs, the G protein-coupled receptor Sphingosine-1-Phosphate Receptor 2 (S1PR2) represents another signaling node potentially linking BA metabolism to the TIME, primarily through interactions with conjugated bile acids (CBAs) (103)

If any side effects arise, they tend to be minor and temporary itching, rash-like patches, tiredness, and transiently high liver enzyme levels