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Of note, many of these cases exhibit CSF oligoclonal bands, Gd-enhancing lesions on MRI and clinical response to immunosuppressionall features very typical of MSindicating that secondary immune responses to a primary trigger can play a significant role in the final clinical phenotype

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Moreover, madecassoside (MAD), isolated from Centella asiatica (Li et al., 2016) could repress the activation of the HGF-induced c-Met-PKC-ERK1/2-Cyclooxygenase-2 (COX-2)-Prostaglandin E2 (PGE2) cascade to inhibit HCC cell proliferation and invasion

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In preclinical studies, Elamipretide has shown promise in mitigating tissue damage following ischemia-reperfusion injury, preserving cardiac function after myocardial infarction, and ameliorating neurodegenerative processes (Birk et al., 2017

Gao, H., Liu, C., Song, S