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Research indicates that individuals with cognitive impairment exhibit impaired neural reserve, reduced neural plasticity, dysfunction in key neurotransmitter systems (e.g., the cholinergic system), and exhausted compensatory mechanisms

Jeffers et al., 1997)

Together, these data indicate that dopamine increases viral replication by activating a noncanonical signaling pathway mediated by both types of dopamine receptors to induce changes in CCR5 that increase HIV entry into myeloid cells

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