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[62, 63, 64] Earlier studies had shown that hCDR1 induced anergy in antigen presenting cells (APCs) and the generation of Tr1 T regs , which expressed tolerance-associated genes

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Unlike human growth hormone, which can induce hyperglycemia and reduce insulin secretion during extended use, AOD-9604 showed no adverse effect on insulin sensitivity even in long-term animal studies confirmed through euglycemic clamp techniques