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130 , e106 (2020)

Evidence boundary The published trial record describes safety more clearly than efficacy

A surrogate endpoint may reduce the duration length and cost of clinical trials and be a better indicator of drug efficacy with hematological indices better served as secondary endpoints

Glutathione may also react with other medications, such as blood thinners

Studies have found that long-term high-fat diet significantly activates the NF-B signaling pathway, manifested as increased hepatic p-IB and p-p65 protein levels, and markedly elevated expression of pro-inflammatory factors TNF- and IL-1 in serum and liver tissue [38]