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Since its inception in the early 1940s, Waddingtons concept of epigenetics took on additional meanings until encompassing the current notion of stochastic or environment-induced modifications of histone proteins or DNA without changes in the DNA sequence itself that alter the accessibility of genes to transcription factors [9]

Phosphate is a specific signal for induction of osteopontin gene expression

Treatment with LCn significantly ( P 0.05) improved the level of these reproductive hormones in the LCn + CYP group in contrast to the CYP-treated group

The following qRT-PCR conditions were used: 40 cycles of 94 C for 15 s, annealing temperatures as indicated in Table (1) for 30 s, and extension temperature at 72 C for 20 s were performed after 95 C for 4 min