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Studies show REV-ERB and REV-ERB nuclear receptors control circadian rhythm and metabolic genes

Knockdown of NNMT elicits heightened energy expenditure in adipose and hepatic tissues, mitigates lipid accumulation, and enhances insulin sensitivity

5-Amino-1MQ is an orally bioavailable, cell-permeable small molecule that potently inhibits NNMT (nicotinamide N-methyltransferase), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide (1-MNA)

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In experimental studies, AOD-9604 has been observed to stimulate fat oxidation , increase energy expenditure , and reduce adipose tissue accumulation through activation of beta-adrenergic lipolytic pathways