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Chronic high temperatures can cause the inactivation of protein synthesis and DNA repair processes

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In response to oxidative and nitrosative stress, cells increase their antioxidant defenses through activation of nuclear factor erythroid 2related factor (Nrf2), an important transcription factor (Maes et al., 2011)

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The pathogenesis involves both innate and adaptive immune responses targeting bile duct cells and various extrahepatic tissues [241,242,243]

23,44 For example, Bouffi et al., 23 show that IL-33 stimulation of eosinophils results in the alteration of over 500 genes resulting in the upregulation of various factors such as IL-6, IL-13, CCL17, and TGF-