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In addition, metallothionein 3 (MT3) can extract Cu 2 + from amyloid- or -synuclein complexes and facilitate its reduction to Cu + , a property attributed to its flexible N-terminal -domain containing a unique threonine insertion at position 5 that distinguishes MT3 from other metallothionein isoforms 195,196

In its function as a cellular caretaker, attenuation of GSTP1 expression or activity by either genetic (e.g., deletion or mutation) or epigenetic alterations may reduce cellular detoxification capacity ( Figure 2 )

These assays although useful for comparing antioxidant capacities of a variety of chemical or biological samples, do not give information about the antioxidant reactions that may occur in in vitro or in vivo cancer models

[DOI] [PMC free article] [PubMed] [Google Scholar] Brown GL, Lum RT, Schow SR, Maack C, Vollmer C, Gomez R, Delioukina M, Boulos L, Laxa B, Brown J and Rosen LS

-Glutamyl transpeptidase catalyses the extracellular detoxification of cisplatin in a human cell line derived from the proximal convoluted tubule of the kidney

AOD 9604 fat reduction in obese subjects Heffernan MA et al