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In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness

PubMed , StatPearls , StatPearls Publishing, 2025

J Mol Pharm Org Process Res
To date, there is no treatment to effectively stop or reverse the progression of neuropathy [56]

[DOI] [PubMed] [Google Scholar] 50.Czeredys M, Samluk L, Michalec K, Tulodziecka K, Skowronek K, Nalecz KA

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