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The most well-known recent approvals include semaglutide (Ozempic/Wegovy, 2017/2021), tirzepatide (Mounjaro/Zepbound, 2022/2023), and bremelanotide (Vyleesi, 2019)

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**Key Strengths:** Directly targets the root cause of leaky gut Oral administration for convenience Specific mechanism of action with clear rationale Particularly effective for gluten-related gut issues Minimal drug interactions **Key Weaknesses:** Most limited research base of the three options Highest cost per month Longest time to see noticeable effects May cause mild gastrointestinal upset initially Narrow focus may miss other healing opportunities **Ideal Patient Profile:** Larazotide suits patients with confirmed leaky gut syndrome, particularly those with celiac disease or non-celiac gluten sensitivity

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If GHK-Cu can mobilize resident stem cell populations in wound beds and aging tissues, this would help explain the breadth of its regenerative effects across different tissue types