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We strongly recommend it, but no - you do not have to have one if you choose not to, though we do explain why this is storngly recommended

Omega-3 fatty acids EPA and DHA: health benefits throughout life

Remember, it only takes one poor decision to cause a tragedy that can be prevented

However, vitamin B12 can be stored in the liver for a long time, so it does not easily become deficient

Persistent metabolic disruption is a signal to reconsider whether IGF-1 LR3 is appropriate for your situation

For context on SAMe and related evidence limits, see the NIH NCCIH resource S-Adenosyl-L-Methionine (SAMe): In Depth