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However, the SASP factors secreted by senescent cells induce CD38 expression and increase CD38-NADase activity in non-senescent immune cells and endothelial cells 27

Anti-CD38 antibodies that specifically inhibit CD38 NADase activity without cytotoxic effects may become an important tool for the boosting NAD, immune modulation, and for use in age-related diseases

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Prkacin I., Separovic J., Aralicia G., Perovic D., Gjurasin M., Lovric-Bencic M., Stancic-Rokotov D., Staresinic M., Anic T., Mikus D., et al