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Statistical comparisons were made using one-way ANOVA with Tukeys multiple comparisons test ( a , b , e , f , g ), or two-tailed unpaired t-test ( i - n , p , r )

Acting as a co-factor for several antioxidant enzymes

Parkinsons disease PD is characterized by degeneration of dopaminergic neurons, affecting millions of people worldwide and ranking as the second most common condition of its kind after Alzheimers disease 32

In the same model it was found that treatment increased responses to polyinosinic:polycytidylic acid (poly I:C), an antiviral ligand, and type I interferons, further supporting the antiviral properties of vitamin C in airway cells and potentially providing a way to combat air pollution-induced dysregulation of antiviral immune responses