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platensis has been used by humans for centuries as evidenced by reports from Mexico and Central Africa.2 Currently, it is widely used as a nutraceutical namely for the prevention of diabetes, although numerous other biological effects have been ascribed to this alga.2 Among many potentially-bioactive substances, PCB and chlorophylls, represent compounds of particular interest due to their structural resemblance to bilirubin, a potent antioxidant, atheroprotective, and anti-proliferative agent.24 In fact, the anticancer action of bilirubin has been attributed to its effects on mitochondria28 as well as intracellular signalization.29 In addition, bilirubin was found to be a widespread inhibitor of protein phosphorylation,30 which might account for these biological properties

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Thus, with such general limitations [14], skipping its interaction with many molecular pathways [36,37,43,44,45,46,47,48,49,50,51] (in particular, improved anabolic and counteracted catabolic pathways implemented in the recovery of the tumor-induced muscle cachexia [51]), the sustained, safe, and reproducible delivery of the BPC 157 is effective outside general peptide terms