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PMID: 37975903
The vagus nerve acts like a superhighway between your gut and brain
In patients already receiving an opioid analgesic, prescribe a lower initial dose of the benzodiazepine or other CNS depressant than indicated in the absence of an opioid, and titrate based on clinical response

"A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility"

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In some embodiments, the otic formulation or composition comprises about 11% by weight of the poloxamer
