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Curcumin can directly neutralize ROS and reactive nitrogen species, reducing oxidative damage to lipids, proteins, and DNA in dopaminergic cells (70)

For instance, in T cells, stimulation leads to ROS generation and activation of the NRF2 pathway

With site-directed mutagenesis, four Q residues in the GST tag were identified as polyamination sites

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Elevated levels of circulating mtDNA and inflammatory cytokines such as IL-6 and IFN- have been reported in the CSF and serum of PD patients, particularly those carrying biallelic PINK1 or Parkin mutations [165]