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Description
Dexamethasone reduces the connective-tissue inflammation that drives fluid leakage, while hydrochlorothiazide increases urine production to remove fluid that has already accumulated, producing a combined anti-oedematous effect

doi:10.1080/09638288.2017.1362708

One possible explanation is that your body is undergoing an adjustment period

Hydration strategy Reduced food intake means reduced water intake from food sources (food provides roughly 20% of your daily water)

Bedtime dosing works well because sleep represents a natural fasted state

Its been smooth sailing and Im sure it will always be
