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[13] [15] Is it safe to use during pregnancy or breastfeeding

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On the other hand, despite sCT-induced neuronal activation in the AP of RAMP 1/3 KO HFD-fed mice, it did not result in an anorectic effect on day 1 of treatment suggesting the necessity of AMY 1 R and AMY 3 R to induce anorexia and that this circuitry is independent of signalling at the core CTR receptor

And this is the other thing that happens, is people get impatient and they just keep cranking up the dose, and cranking it, and cranking it, and cranking it

In other patients, the dose may not yet be optimized, or side effects may prevent adequate titration

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