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Assessment of the goiter prevalence in a population is used to define the severity of iodine deficiency, as well as to monitor the long-term impact of sustained salt iodization programs (4, 11)

The ability of these allelic variants to catalyze the GSH conjugation of reactive metabolites of acetaminophen, clozapine and diclofenac formed by bioactivation in in vitro incubations by human liver microsomes and drug-metabolizing P450 BM3 mutants has been studied [34]

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