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The cumulative effect builds quietly under the surface

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The specific activity of the Y398A mutant was significantly decreased toward both tyrosine and DOPA

[PubMed 2524968] 1318

doi: 10.1038/s42255-021-00407-6

Referred to as nitrosative stress it causes damage primarily to vascular tissue and has been demonstrated to be increased with diabetes ( - biologically has a short half-life but has the ability to diffuse across cell membranes and depending on the cell environment can cause a nitrosylation of proteins and peroxidation of lipids ( As previously discussed, endothelial dysfunction occurs early in diabetes and is a primary factor in the development of diabetic vascular disease, which contributes to the development of DPN
