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Recent studies have shown that drugs such as metformin, itraconazole and pimobendan have been repositioned to regulate metabolic and epithelial-mesenchymal transition (EMT) pathways, effectively inhibiting BC progression (Kandasamy et al., 2024)

These discrepancies underscore the challenges of modelling human genetic variation in experimental systems and emphasise the importance of context-specific follow-up [10]

10.1093/jb/mvp149 J

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