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Activation of mTORC1 leads to the phosphorylation of S6 kinase-1 (S6K1) and eukaryotic translation initiation factor 4E-binding protein-1 (4EBP1), which stimulates protein translation and cell growth (Wolfson and Sabatini, 2017)

Sebaratnam DF, 2022, 'Atenolol as treatment for hepatic hemangiomas in a premature infant', Pediatrics and Neonatology , 63, pp

[DOI] [PMC free article] [PubMed] [Google Scholar] 197.Leachman S.A., Lucero O.M., Sampson J.E., Cassidy P., Bruno W., Queirolo P., Ghiorzo P

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In contrast, features suggestive of higher growth potential and probable malignant histology include thickness greater than 1.5 mm, nonuniform coloration of the lesion, prominent clumps of lipofuscin pigment on the surface of the lesion, and serous subretinal fluid overlying and surrounding the lesion