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The dose was 50 mg/kg mixed into 200 ml of D5W infused over ~1 h 1x per week

Physiol Genomics 34 , 112126, doi: 10.1152/physiolgenomics.00239.2007 (2008)

XAV-939, a Tankyrase inhibitor, has been shown to promote ferroptosis in lung cancer cells by inducing the down-regulation of SLC7A11, and inhibiting the progression of lung cancer by down-regulating lncRNA MIR503HG, sponging miR-1273c and regulating SOX4 expression [189]

A preclinical half-life estimate of under 30 minutes is part of why local placement gets discussed

Each domain was rated as presenting a low, high, or unclear risk of bias, according to predefined criteria