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Sci Total Environ 562:170178 Zhao HM, Hu RW, Chen XX, Chen XB, L H, Li YW, Wong MH (2018) Biodegradation pathway of di-(2-ethylhexyl) phthalate by a novel Rhodococcus pyridinivorans XB and its bioaugmentation for remediation of DEHP contaminated soil

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This differs fundamentally from receptor agonist medications where downregulation requires dose escalation